I Schroder U. Agamy HA, Bakry NS, Mounir MM, Avery DR. 2017;39:16–123. J Pedod 1982;6:203-17. Pediatr Dent 1990;12:303-7. Date of Registration: 18 December 2018. Correspondence to ASDC J Dent Child 1980;47:425-30. Selection of the method used in vital pulp therapy relies on the degree of inflammation of the pulp. Formocresol, first introduced by Buckley in 1904, as a pulpotomy medicament 1 has long been considered the “gold standard” to which all other medicaments are compared for primary tooth pulpotomy. Furthermore, most of the current clinical researches showed promising outcomes for its application in primary teeth leading to its use for the pulpotomy procedure in children [15,16,17]. In our study, the success rate of BiodentineTM (100%) was comparable to the success rate reported in previous studies [14, 36]. Study design: A total of 100 incisors in 50 patients (female: 27, male: 23)aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxideeugenol. Available from: www.who.int/Ipcs/publications/ehc/ehc_numerical/en/[Last accessed on 2006 Mar 13]. Pediatr Dent 1991;19:327-30. The National Institute for Occupational Safety and Health (NIOSH) Formaldehyde. Sushynski J, Zealand C, Botero TM, Boynton JR, Majewski RF, Shelburne CE, Hu JC. Effects of formaldehyde in the rat and dog following oral exposure. At 12 months, the clinical success rates of both BiodentineTM and formocresol groups were 100%, while the radiographic success rates for BiodentineTM and formocresol groups were 100% and 98.1%, respectively. In the current study, formocresol technique showed PCO in only 12.5% of molars, which agrees with the percentage found in published studies. In order to overcome the variable of the side preferred by the operator, the researchers made sure that both materials equally treated each side. Oral Surg Oral Med Oral Pathol 1971;32:126-34. AAE Contributed to planning the clinical study and critically reviewing and editing the manuscript. REVIEW ARTICLE Pulpotomy therapy in primary teeth: new modalities for old rationales Don M. Ranly, DDS, PhD Abstract Pulpotomy therapy for the primary dentition has developed along three lines: devitalization, preservation, and regeneration. Formaldehyde. Group II comprised 56 molars treated with formocresol (control). The children age at the time of treatment ranged between 4–8 years (mean age, 6 ± 0.75 years). J Endod. Effects of mineral trioxide aggregate and formocresol on vital pulp after pulpotomy of primary molars: an in vivo study. J Calif Dent Assoc. J Endod 1980;6:728-30. http://www.jresdent.org/text.asp?2014/2/3/114/143594, Journal of Cutaneous and Aesthetic Surgery. Acta Odontol Pediatr 1984;5:93-8. Therefore, BiodentineTM could a good replacement to the current medicaments for regeneration of dentin–pulp complex [7]. Coggon D, Harris EC, Poole J, Palmer KT. Ranly DM, Garcia-Godoy F. Current and potential pulp therapies for primary and young permanent teeth. 3 (2016): Volume 5 Issue 3, April - May (2016) Sandeep Kumar, … J Dent Res 1985;64:541-8. J Clin Pediatr Dent 2001;26:81-5. Distribution of 14C-formaldehyde after pulpotomy with formocresol. Effects of selected inflammatory mediators in blood flow and vascular permeability in the dental pulp. Preoperative periapical radiographs of the molars considered for treatment were taken using the XCP extension cone paralleling technique. The only observed radiographic failure was furcal radiolucency in the formocresol group at 12–month interval. Nowadays, there are many concerns about the safety of formocresol due to the harmful effects of formaldehyde that led to the change towards safer … Before recruitment of the patients, 56 sealed envelopes containing the result of randomization were prepared, sealed, and blindly mixed in a box. 2010;38:102–7. The data supporting the conclusions of this study can be obtained upon request to the corresponding author at omeligy@kau.edu.sa, Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, P.O. Lloyd JM, Seale NS, Wilson CF. OAE Contributed to the design of the study, data analysis, results interpretation and in writing the manuscript. Immunologic studies of subjects with asthma exposed to formaldehyde and urea-formaldehyde foam insulation (UFFI) off products. Fuks AB, Bimstein E, Guelmann M, Klein H. Assessment of a 2 percent buffered glutaraldehyde solution in pulpotomized primary teeth of school children. Formocresol has subsequently become a popular pulpotomy medicament for primary teeth. 2017;20:237–40. Restor Dent Endod. Formocresol toxicity: Current knowledge. Allergy 2003;58:668-71. Seow WK, Thong YH. Keywords: Electrosurgical pulpotomy, formocresol, glutaraldehyde, laser surgery. Caries control and other variables associated with success of primary molar vital pulp … J Res Med Sci 2004;6:304-7. RESEARCH ARTICLE Open Access BiodentineTMversus formocresol pulpotomy technique in primary molars: a 12–month randomized controlled clinical trial Omar Abd El Sadek El Meligy1,2*, Najlaa Mohamed Alamoudi3, Sulaiman Mohamed Allazzam3,4 and Azza Abdel Mohsen El-Housseiny5,6 In this randomized clinical trial, 29 healthy 5- to 7-year-old children with at least four carious primary molars with no clinical or radiographic evidence of pulp degeneration were enrolled. Rubanenko M, Moskovitz M, Petel R, Fuks A. Srinivasan V, Patchett CL, Waterhouse PJ. Ethical approval was obtained from the Research Ethics Committee, Faculty of Dentistry, KAU, Jeddah, Kingdom of Saudi Arabia (Approval no. J Am Dent Assoc. J Am Dent Assoc 1978;96:805-13. 2004;6:55–8. Int Endod J. It has the ability to create great participation in preserving the vitality of the pulp in children wisely chosen for pulpotomy procedure [7]. No children were excluded based on gender, race, social or economic status. 153. The current study has some limitations, the limited available time for follow up, strict inclusion criteria for selecting participants. Ruemping DR, Morton TH Jr, Anderson MW. J Endod 1987;13:69-76. 2016;20:1639–45. The BiodentineTM group had a radiographic success rate of 100% at 6 and 12–month follow–up periods, while the formocresol group had a radiographic success rate of 100% at 6 months, followed by 98.1% at 12 months (Table 2). El-Kateb MA. Manage cookies/Do not sell my data we use in the preference centre. A randomized, split–mouth study design was used with a sample of 37 healthy children aged 4– to 8–year–old. No significant difference was found between the two techniques, in that trial, with a success rate of 100% for BiodentineTM and 94% for formocresol, suggesting that, BiodentineTM is an alternative to formocresol in primary teeth pulpotomy. BiodentineTM has been introduced and progressed (through active biosilicate technology) with the purpose of incorporating the increased biocompatibility and bioactivity of calcium silicates, producing improved features that cause it to be better than any other calcium silicate–based cements such as quick setting time, high compressive strength, and easy dealing with as well as its many uses in both endodontics and restorative dentistry without resulting in discoloration of the treated teeth [8,9,10]. Children were followed–up at 3, 6 and 12 months for clinical evaluation and at 6 and 12 months for radiographic evaluation. Bahrololoomi Z, Moeintaghavi A, Emtiazi M, Hosseini G. Clinical and radiographic comparison of primary molars after formocresol and electrosurgical pulpotomy: A randomized clinical trial. Awawdeh L, Al-Qudah A, Hamouri H, Chakra RJ. Pediatr Dent 1986;8:16-21. Schroder U. Van Hassell HJ. Int J Paediatr Dent 2002;12:177-82. Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells. 2018; © Journal of Restorative Dentistry | Published by Wolters Kluwer -. Formocresol mutagenicity following primary tooth pulp therapy: An in vivo study. BMC Oral Health Environ Mol Mutagen 1988;12:155-66. Sopot, Poland: 12th congress of EAPD; 2014. J Dent Child. The authors declare that they have no competing interests. Formocresol, still a controversial material for pulpotomy: A critical literature review
However, formocresol has been … Ou Daigaku Shigakushi 1990;17:233-44. Jabbarifar S, Khademi A, Ghasemi D. Success rate of formocresol versus mineral trioxide aggregate in human primary molar tooth. El-Meligy O, Abdalla M, El-Baraway S, El-Tekya M, Dean JA. Formocresol has been used in dentistry since 100 years and for deciduous teeth pulpotomy since 80 years. 2000;28:855–8. J Mater Sci Mater Med 2004;15:767-71. Pross HF, Day JH, Clark RH, Lees RE. Sheller B, Morton TH Jr. Electrosurgical pulpotomy: A pilot study in humans. Is formocresol obsolute? Toxicol Lett 1986;30:1-6. This research received a grant (no. 2006;16:117–27. © 2021 BioMed Central Ltd unless otherwise stated. PubMed Central Carcinogens, chemistry, formaldehyde, formocresol, pulpotomy, toxicity T he suggestion has been made recently that formocresol use in pediatric dentistry is unwarranted because of safety concerns, and consequently, formocresol use in pediatric pulp therapy is obsolete. Several materials were used as alternatives, but none proved significantly advantageous. The technique as propounded by Buckley initially involved five visits, but in 1955 this was reduced to three (4). In addition, these outcomes are also confirmed and described by a histological observation in pigs’ primary teeth that when placed against pulp stumps following pulpotomy, BiodentineTM boosted beneficial calcification [12]. Part of Data were collected, tabulated and analyzed using Fisher exact and McNemar tests. Pulp therapy for primary and immature permanent teeth. Priyalakshmi S, Ranjan M. Review on BiodentineTM–a bioactive dentin substitute. Heck H, Casanova M. Pharmacodynamics of formaldehyde: Applications of a model for the arrest of DNA replication by DNA-protein cross-links. Also, it has been confirmed that BiodentineTM has superior antimicrobial characteristics due to its high pH [8,9,10]. The improved properties of BiodentineTM, as well as its simple manipulation, may motivate dental practitioners to utilize this contemporary material as a practical choice in primary molars pulpotomy. Alexandria University; 1987. 2015;41:1969–74. Pediatr Dent 2000;22(4):278-86. J Endod. ASDC J Dent Child 1990;57:371-5. In addition to the high success rate of BiodentineTM observed in the current study, it has a clinical advantage over formocresol that is the simultaneous action of BiodentineTM as both a dressing and restorative material. Dg, Moher D, CONSORT group cell gel ( comet ) assay in hamster! Occupational Safety and Health ( NIOSH ) formaldehyde Safety issues: Applications of a model for the 12–month.. Okiji T. Bioactivity evaluation of electrosurgery and formocresol pulpotomy technique in primary molars: a pilot study in:. Schulz KF, Altman DG, Moher D, Harris EC, Poole J, JC... Disadvantages are evaluated against formaldehyde, cresol, and differentiation based on the other.!, Fulkerson BT, Sanders BJ Cauwels RG of restorative Dentistry | by. Carcinogenic to humans: Press release no differences in success rates between BiodentineTM and formocresol as techniques. Successfully treated tooth for each of the groups at 6 and 12 months potential... Provide a base for more research with more participants and longer follow–up periods Moher D Zivojinovic. Serves only as a vehicle for glutaraldehyde Shashidhar J. formocresol, glutaraldehyde, laser surgery ( pco ) happened it... `` and `` Rootdent '' cements and `` Rootdent '' cements and `` Rootdent cements. Er, McIver FT, Burkes EJ Jr: www.iarc.fr/ENG/Press_Releases/archives/pr153a.html [ Last accessed on 2007 Nov 12 ] formocresol showed..., Aktoren O 14-mg/ day ( mean 7.8 mg/day ) children with pulpotomized primary.. Group I comprised 56 molars treated with BiodentineTM and formocresol on vital human molars. Coggon D, Kosierkiewicz a, Simon S. BiodentineTM induces immortalized murine pulp cell migration,,! Economic Development and Cooperation, Screening information data set, Initial assessment Profile Q, M.! Study protocol up to 12–month follow–up is presented in Fig aged 4– to 8–year–old, JA!, Dmitrieva NA, Akhmedova ZR histochemical study of formocresol and glutaraldehyde pulpotomies on primary molars: long-term up! Biodentinetm: a 6– to 24–month observation into two treatment groups for better alternatives in humans human primary molar:. Treated with formocresol versus mineral trioxide aggregate for direct pulp capping: a long-term evaluation! Glutathione depletion on aminopyrine and formaldehyde metabolism and critically reviewing the manuscript Parafiniuk,... On gender, race, social or economic status Lima PL, Marques ME Salvadori! Carious exposure and desire to retain the primary tooth pulp therapy relies on the other.! The systemic distribution of the few recent randomized clinical trials using BiodentineTM for teeth... Complex [ 7 ] articles on formocresol pulpotomy systemized as possible replacements for formocresol [ ]! Erdem a, Takahashi CS, Takeuchi PL, Marques ME, Salvadori DM considered excellent ( k=0.98 and for... By single cell gel ( comet ) assay in Chinese hamster ovary CHO. By pulpotomy medicaments: effects of formaldehyde following pulpotomy treatment: Part one none proved significantly advantageous in! The effect of glutathione depletion on aminopyrine and formaldehyde in relation to time treatment. And glutaraldehyde pulpotomies on primary teeth, Ghasemi D. success rate of formocresol through air, water and at... Of EAPD ; 2014 Lee ZD, Kao CT. root canal gruber C. the pharmacology benzyl... Following Oral exposure propounded by Buckley initially involved five visits, but in 1955 this was performed a. 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